Study description: The Prospective Longitudinal Study aims to continue the research successfully conducted during CENC Cycle 1, as well as expand the current active cohort of 1,500 Service Members and Veterans. Throughout the duration of CENC Cycle 2, the Prospective Longitudinal Study will refine methods, enhance analyses, and apply results to identify predictors and longitudinal effects of mTBI.

If you are a Service Member or Veteran interested in being a participant for this study, click on the following link for additional information: Participate in CENC Research.

Study description: The Retrospective Database Study aims to maintain, augment, and refine the database of 1.6 million Veterans, created during CENC Cycle 1, as well as expand analyses and application of results. During CENC Cycle 2, the Retrospective Database Study will conduct analyses to identify, examine, and elucidate outcome predictors, comorbidities, and neurodegenerative sequelae associated with mTBI, ultimately aiming to apply results to development of prognostic models.

Study description: The Phenotypes Study

Study description: The Health Economics Study

Study description: The Novel Neuroimaging Study

Study description: The Biomarkers Discovery Study

Core description: The Coordinating Center manages and provides support for all consortium activities. Through individual and collective collaboration with CENC leadership, Core Directors, and Study personnel, the Coordinating Center ensures regulatory compliance, monitors progress, facilitates communication, and offers assistance, in order to promote success for each project, as well as the unified consortium.

Core description: The Data and Biostatistics Core centrally and securely maintains all consortium data, provides biostatistical support, assists with study design functions, conducts data processing, and performs biostatistical analyses for manuscripts and presentations.

Core description: The Biomarkers Core manages the transfer, storage, and processing of all blood and saliva samples collected, for all consortium projects that conduct biospecimen collection procedures.

Core description: The Neuroimaging Core facilitates acquisition, review, transfer, collation, tracking, analysis, reporting, storage, and interpretation of neuroimaging data, for all consortium projects that conduct imaging procedures.